2-Bromoethyl ethyl ether → HCID 23035332, compound

HRID 1709992Notes

Reaction equation

HRID 1709992 reaction equation
[CH2:1]([O:3][CH2:4][CH2:5]Br)[CH3:2].[OH:7][C:8]1[CH:23]=[CH:22][C:21]([O:24][CH2:25][C:26]([F:29])([F:28])[F:27])=[CH:20][C:9]=1[C:10]([NH:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=1)=[O:11]>>[CH2:1]([O:3][CH2:4][CH2:5][O:7][C:8]1[CH:23]=[CH:22][C:21]([O:24][CH2:25][C:26]([F:29])([F:27])[F:28])=[CH:20][C:9]=1[C:10]([NH:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=1)=[O:11])[CH3:2]

Participants

3

Reactant 2

HCID 611412-Bromoethyl ethyl etherHCID 15055922HCID 15055922, compound

Product 1

HCID 23035332HCID 23035332, compoundYield 35.1%

Procedure

Using the general method of Example I Part A, 4.3 g (0.028 mole of 2-bromoethyl ethyl ether was reacted with 6.52 g (0.02 mole) of 2-hydroxy-N-(2-pyridylmethyl)-5-(2,2,2-trifluoroethoxy)benzamide to provide 2.8 g of white crystalline 2-(2-ethoxyethoxy)-N-(2-pyridylmethyl)-5-(2,2,2-trifluoroethoxy)benzamide, m.p.90°-94° C. The structure was confirmed by nuclear magnetic resonance spectroscopy.

Sources & evidence

ORD record
ord-b3c32fb3468d4db9b124628c909f85fd
Source dataset
uspto-grants-1990_08
Patent number
US04952574

Reaction notes

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