Pyridine → HCID 135617167, compound

HRID 1710196Notes

Reaction equation

HRID 1710196 reaction equation
[NH2:1][C:2]1[N:3]([CH2:13][CH:14]2[CH2:19][CH2:18][CH2:17]C[S:15]2)[C:4]2[N:5]=[C:6]([NH2:12])[NH:7][C:8](=[O:11])[C:9]=2[N:10]=1.CN([CH:23]=[O:24])C.N1C=CC=C[CH:26]=1.[C:31](OC(=O)C)(=[O:33])[CH3:32]>CCOCC>[O:11]=[C:8]1[NH:7][C:6]([NH:12][C:31](=[O:33])[CH3:32])=[N:5][C:4]2[N:3]([CH2:13][C:14]3[S:15][CH:17]=[CH:18][CH:19]=3)[C:2]([NH:1][C:23](=[O:24])[CH3:26])=[N:10][C:9]1=2

Participants

6

Reactant 4

HCID 1049PyridineHCID 6228DimethylformamideHCID 7918Acetic AnhydrideHCID 135970726HCID 135970726, compound

Product 1

HCID 135617167HCID 135617167, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A mixture of 8-amino-9-[(2-thianyl)methyl]guanine (0.5 g; 1.88 mmol), DMF (10 ml), pyridine (5 ml), and acetic anhydride (5 ml) was stirred at room temperature for 36 hours. The mixture was diluted with ether (50 ml) and filtered to give analytically pure product, mp 243°-4° C.

Workup

  1. filtrationfiltered
  2. customto give analytically pure product, mp 243°-4° C.

Sources & evidence

ORD record
ord-d2f0a3662fa34ce7b065c6c16fee439a
Source dataset
uspto-grants-1990_08
Patent number
US04952693

Reaction notes

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