Hydrochloric Acid → 3-Difluoromethoxy-N-(4-methoxy-3-piperazin-1-yl-phenyl)-benzenesulfonamide Hydrochloride

HRID 1710602Notes

Reaction equation

HRID 1710602 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[C:18]([NH:20][S:21]([C:24]3[CH:29]=[CH:28][CH:27]=[C:26]([O:30][CH:31]([F:33])[F:32])[CH:25]=3)(=[O:23])=[O:22])[CH:17]=[CH:16][C:15]=2[O:34][CH3:35])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:36]>C(O)(C)C>[ClH:36].[F:33][CH:31]([F:32])[O:30][C:26]1[CH:25]=[C:24]([S:21]([NH:20][C:18]2[CH:17]=[CH:16][C:15]([O:34][CH3:35])=[C:14]([N:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)[CH:19]=2)(=[O:23])=[O:22])[CH:29]=[CH:28][CH:27]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 576995064-[5-(3-Difluoromethoxy-benzenesulfonylamino)-2-methoxy-phenyl]-piperazine-1-carboxylic Acid tert-butyl Ester

Product 1

HCID 252567323-Difluoromethoxy-N-(4-methoxy-3-piperazin-1-yl-phenyl)-benzenesulfonamide Hydrochloride

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

0.17 g of 4-[5-(3-Difluoromethoxy-benzenesulfonylamino)-2-methoxy-phenyl]-piperazine-1-carboxylic acid tert-butyl ester (0.331 mmol) from preparation example 1 were treated with 1 ml of 5 N HCl in isopropanol for 3 h at 35° C. The solvent was evaporated and 5 mL of diethyl ether were added. The product started to crystallize upon scratching the glass surface. The solvent was evaporated and the solid dried thoroughly at room temperature to yield 0.125 g of title compound.

Workup

  1. customThe solvent was evaporated
  2. addition5 mL of diethyl ether were added
  3. customto crystallize
  4. customThe solvent was evaporated
  5. customthe solid dried thoroughly at room temperature

Sources & evidence

ORD record
ord-9f29f5d42756499f816fc48959ad4f81
Source dataset
uspto-grants-2010_09
Patent number
US07790727B2

Reaction notes

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