Hydrochloric Acid → 3-Difluoromethoxy-N-(4-methoxy-3-piperazin-1-yl-phenyl)-N-methyl-benzene-sulfonamide Hydrochloride

HRID 1710603Notes

Reaction equation

HRID 1710603 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[C:18]([N:20]([S:22]([C:25]3[CH:30]=[CH:29][CH:28]=[C:27]([O:31][CH:32]([F:34])[F:33])[CH:26]=3)(=[O:24])=[O:23])[CH3:21])[CH:17]=[CH:16][C:15]=2[O:35][CH3:36])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:37]>C(O)C.C(O)(C)C>[ClH:37].[F:34][CH:32]([F:33])[O:31][C:27]1[CH:26]=[C:25]([S:22]([N:20]([C:18]2[CH:17]=[CH:16][C:15]([O:35][CH3:36])=[C:14]([N:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)[CH:19]=2)[CH3:21])(=[O:24])=[O:23])[CH:30]=[CH:29][CH:28]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 576995094-{5-[(3-difluoromethoxy-benzenesulfonyl)-methyl-amino]-2-methoxy-phenyl}-piperazine-1-carboxylic Acid tert-butyl Ester

Product 1

HCID 670948603-Difluoromethoxy-N-(4-methoxy-3-piperazin-1-yl-phenyl)-N-methyl-benzene-sulfonamide Hydrochloride

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 3776IsopropanolSolvent

Procedure

0.3 g (0.584 mmol) 4-{5-[(3-difluoromethoxy-benzenesulfonyl)-methyl-amino]-2-methoxy-phenyl}-piperazine-1-carboxylic acid tert-butyl ester from preparation example 2 were dissolved in 8 mL of ethanol and 0.8 mL of 5 N HCl in isopropanol were added. After stirring for 16 h at room temperature, the solvent was evaporated to yield 0.255 g of title compound.

Workup

  1. customthe solvent was evaporated

Sources & evidence

ORD record
ord-becf93b9278b4b4da280962a109c88a7
Source dataset
uspto-grants-2010_09
Patent number
US07790727B2

Reaction notes

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