2-(Methylthio)-4-(trimethylstannyl)pyrimidine → 6-(2-Furyl)-5-[2-(methylthio)pyrimidin-4-yl]pyrazin-2-amine

HRID 1710694Notes

Reaction equation

Br[C:2]1[N:3]=[CH:4][C:5]([NH2:13])=[N:6][C:7]=1[C:8]1[O:9][CH:10]=[CH:11][CH:12]=1.[CH3:14][S:15][C:16]1[N:21]=[C:20]([Sn](C)(C)C)[CH:19]=[CH:18][N:17]=1>C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.Cl[Pd]Cl.CN(C)C=O>[O:9]1[CH:10]=[CH:11][CH:12]=[C:8]1[C:7]1[N:6]=[C:5]([NH2:13])[CH:4]=[N:3][C:2]=1[C:18]1[CH:19]=[CH:20][N:21]=[C:16]([S:15][CH3:14])[N:17]=1

Participants

Conditions

Temperature: 150 °C

Procedure

A microwave oven reactor was charged with 5-bromo-6-furan-2-ylpyrazin-2-ylamine (Preparation 2, 220 mg, 0.91 mmol), 2-methylsulfanyl-4-trimethylstannanylpyrimidine* (500 mg, 1.74 mmol), bis-(triphenylphosphin)palladium (II) chloride (60 mg, 0.08 mmol) and dimethylformamide (2.5 mL). The mixture was heated at 150° C. for 10 min in the microwave oven, then cooled, partitioned between water and ethyl acetate, the aqueous phase extracted twice with ethyl acetate, the organic layers washed with brine, dried (MgSO4) and evaporated. Flash chromatography (dichloromethane to dichloromethane/methanol 95:5) gave the title compound as a yellowish solid (123 mg, 47%). *Prepared according to Sandosham J.; Undheim, K. Tetrahedron 1994, 50 (1), 275-284.

Workup

temperaturecooled
custompartitioned between water and ethyl acetate
extractionthe aqueous phase extracted twice with ethyl acetate
washthe organic layers washed with brine
dry with materialdried (MgSO4)
customevaporated

Sources & evidence

ORD record: ord-5a9cc99e8adb4eaca29c6fafc30b2455
Source dataset: uspto-grants-2010_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07790728B2

Reaction notes

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