HCID 16070453, compound → HCID 16070222, compound

HRID 1710714Notes

Reaction equation

HRID 1710714 reaction equation
[C:1]([C:3]1[C:4]([NH2:20])=[N:5][C:6]([C:15]2[O:16][CH:17]=[CH:18][CH:19]=2)=[C:7]([C:9]2[CH:14]=[CH:13][N:12]=[CH:11][CH:10]=2)[N:8]=1)#[CH:2]>C(O)C.[Pt](=O)=O>[CH2:1]([C:3]1[C:4]([NH2:20])=[N:5][C:6]([C:15]2[O:16][CH:17]=[CH:18][CH:19]=2)=[C:7]([C:9]2[CH:10]=[CH:11][N:12]=[CH:13][CH:14]=2)[N:8]=1)[CH3:2]

Participants

4

Reactant 1

HCID 16070453HCID 16070453, compound

Product 1

HCID 16070222HCID 16070222, compoundYield 88%

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 702EthanolSolvent

Procedure

To a solution of 3-ethynyl-6-(2-furyl)-5-pyridin-4-ylpyrazin-2-amine (Example 65, 50 mg, 0.19 mmol) in ethanol (4 mL) was added platinum dioxide (5 mg). The mixture was hydrogenated at 1 atmosphere and at room temperature for 18 h, filtered, washed with methanol and dichloromethane and evaporated to give the title compound as a white solid (44 mg, 88%).

Workup

  1. filtrationfiltered
  2. washwashed with methanol and dichloromethane
  3. customevaporated

Sources & evidence

ORD record
ord-33e98d90e8f04042b8444d94a4eea1ce
Source dataset
uspto-grants-2010_09
Patent number
US07790728B2

Reaction notes

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