Hydrogen Peroxide → HCID 178433361, compound

HRID 1710814Notes

Reaction equation

HRID 1710814 reaction equation
I.[Cl:2][C:3]1[CH:12]=[CH:11][C:10]([Cl:13])=[C:9]2[C:4]=1[CH:5]([CH3:16])[NH:6][C:7](SC)=[N:8]2.[OH-].[NH4+:18].[OH-].[Na+].OO>C(#N)C.O>[Cl:2][C:3]1[CH:12]=[CH:11][C:10]([Cl:13])=[C:9]2[C:4]=1[CH:5]([CH3:16])[NH:6][C:7]([NH2:18])=[N:8]2

Participants

7

Reactant 4

HCID 784Hydrogen PeroxideHCID 14798Sodium HydroxideHCID 14923Ammonium HydroxideHCID 178503353HCID 178503353, compound

Product 1

HCID 178433361HCID 178433361, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6342AcetonitrileSolvent

Conditions

Temperature
170 °C

Procedure

5,8-Dichloro-4-methyl-2-methylsulfanyl-3,4-dihydro-quinazoline hydroiodide (116 mg, 0.30 mmol) was suspended in a mixture of ammonium hydroxide (0.22 ml, 25% in H2O, 3 mmol) and acetonitrile (0.9 ml), and heated in a microwave oven to 170° C. (30 min). The reaction was cooled in an ice bath and treated with 1N aqueous sodium hydroxide solution (0.9 ml) and 5-6 drops of concentrated solution of aqueous hydrogen peroxide. A little water was added, and the title compound (36 mg, 52%) was filtered off as a white solid.

Workup

  1. temperatureThe reaction was cooled in an ice bath
  2. filtrationthe title compound (36 mg, 52%) was filtered off as a white solid

Sources & evidence

ORD record
ord-a52f4ed69a72466d8c2d477b4f28c55f
Source dataset
uspto-grants-2010_09
Patent number
US07790732B2

Reaction notes

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