Hydrazine hydrate (1:1) → HCID 68774675, compound

HRID 1711197Notes

Reaction equation

HRID 1711197 reaction equation
[C:1]([O:5][C:6](=[O:40])[NH:7][C@@H:8]([CH2:28][N:29]1C(=O)C2C(=CC=CC=2)C1=O)[CH2:9][O:10][Si:11]([C:24]([CH3:27])([CH3:26])[CH3:25])([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)([CH3:4])([CH3:3])[CH3:2].O.NN>CCO>[C:1]([O:5][C:6](=[O:40])[NH:7][C@@H:8]([CH2:28][NH2:29])[CH2:9][O:10][Si:11]([C:24]([CH3:27])([CH3:26])[CH3:25])([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 68773942HCID 68773942, compound

Product 1

HCID 68774675HCID 68774675, compoundYield 77.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

[(S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-ethyl]-carbamic acid tert-butyl ester (1.1 g, 1.92 mmol) was treated with hydrazine hydrate (0.5 ml, 9 mmol) in EtOH (5 ml) at rt over night to give [(S)-1-aminomethyl-2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-carbamic acid tert-butyl ester (640 mg, 75%).

Sources & evidence

ORD record
ord-3c7afa4a5832430c8f6e35f64ac8022d
Source dataset
uspto-grants-2010_09
Patent number
US07790747B2

Reaction notes

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