反应详情

To a 0° C. solution of the alcohol (4.75 g, 20.0 mmol), phthalimide (3.32 g, 22.6 mmol) and PPh3 (6.30 g, 24.0 mmol) in THF (130 ml) under nitrogen was added dropwise DEAD (3.3 ml, 21.0 mmol). The resulting light yellow solution was stirred at room temperature for 3 hours, and then the solvent was removed under reduced pressure, giving crude [(R)-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-1-phenyl-ethyl]-carbamic acid tert-butyl ester as a mixture with triphenylphosphine oxide.

1. customthe solvent was removed under reduced pressure