Tetrahydrofuran → 3-(6-acetylamino-1,2,3,4-tetrahydro-naphthalen-1-yl)-3H-imidazole-4-carboxylic acid isopropyl ester

HRID 171127Notes

Reaction equation

HRID 171127 reaction equation
[CH2:56]1[O:57][CH2:58][CH2:59][CH2:60]1.[N:46]([C:47]([O:48][CH3:49])=[O:50])=[N:51][C:52]([O:53][CH3:54])=[O:55].[OH:1][CH:2]1[c:3]2[cH:4][cH:5][c:6]([NH:12][C:13]([CH3:14])=[O:15])[cH:7][c:8]2[CH2:9][CH2:10][CH2:11]1.[c:27]1([P:28]([c:29]2[cH:30][cH:31][cH:32][cH:33][cH:34]2)[c:35]2[cH:36][cH:37][cH:38][cH:39][cH:40]2)[cH:41][cH:42][cH:43][cH:44][cH:45]1.[nH:16]1[cH:17][n:18][c:19]([C:21](=[O:22])[O:23][CH:24]([CH3:25])[CH3:26])[cH:20]1>>[CH:2]1([n:18]2[cH:17][n:16][cH:20][c:19]2[C:21](=[O:22])[O:23][CH:24]([CH3:25])[CH3:26])[c:3]2[cH:4][cH:5][c:6]([NH:12][C:13]([CH3:14])=[O:15])[cH:7][c:8]2[CH2:9][CH2:10][CH2:11]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 11776TriphenylphosphineHCID 351621Azodicarboxylic acid dimethyl esterHCID 67546890N-(5-hydroxy-5,6,7,8-tetrahydro-naphthalen-2-yl)acetamideHCID 178459416HCID 178459416, compound

Product 1

HCID 591993953-(6-acetylamino-1,2,3,4-tetrahydro-naphthalen-1-yl)-3H-imidazole-4-carboxylic acid isopropyl ester

Sources & evidence

ORD record
ord-40f21641a3e242a59e892700752f31ec
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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