4-Aminobenzonitrile → 4-Amino-3-bromobenzonitrile

HRID 1711314Notes

Reaction equation

[NH2:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1.C1C(=O)N([Br:17])C(=O)C1>>[NH2:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[Br:17]

Participants

Reactant 2

HCID 133964-Aminobenzonitrile

HCID 67184N-bromobutanimide

Product 1

HCID 15152794-Amino-3-bromobenzonitrile

Procedure

The title compound was prepared from 4-aminobenzonitrile (2.04 g, 17.2 mmol) and NBS (3.07 g, 17.2 mmol) according to the procedure in Example 16, step (b) (2.53 g, 75%). Mass Spectrum (ESI, m/z): Calcd. for C7H5BrN2, 196.9 (M+H), found 196.7.

Sources & evidence

ORD record: ord-4eb487c9b3a840c992e532c4c5b8d7ff
Source dataset: uspto-grants-2010_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07790724B2

Reaction notes

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