反应详情

To a solution of 0.19 mmol 2-isopropoxy-5-methanesulfonyl-benzoic acid (Example A1) in 1 ml N,N-dimethylformamide were added successively 0.29 mmol TBTU, 0.97 mmol N-ethyldiisopropylamine and 0.19 mmol 4-(piperidin-4-yloxy)-pyridine. The reaction mixture was stirred at RT for 16 h and then concentrated in vacuo. Reversed phase HPLC (acetonitrile/water) afforded the title compound as amorphous white solid (yield 75%). MS (m/e): 419.2 (M+H+, 100%).

1. concentrationconcentrated in vacuo