反应详情

温度

47.5 °C

Ziprasidone (5 g) and 50 mL of acetic acid were placed into a round bottom flask and heated to 45-50° C. Added was 25 mL of aqueous hydrochloric acid slowly to the mixture over 20 min. Then the reaction mixture was refluxed. Water (10 mL) was added, followed by addition of 50 mL of Isopropanol. The reaction mass was cooled to 50° C. and distilled off the solvent completely under vacuum. The material formed was scratched from the flask.

1. additionAdded
2. customover 20 min
3. temperatureThen the reaction mixture was refluxed
4. temperatureThe reaction mass was cooled to 50° C.
5. distillationdistilled off the solvent completely under vacuum
6. customThe material formed