反应详情

2,4-pentanedione (205.4 ml, 2.0 mol), acetone (100 ml), n-butyl bromide (54 ml, 0.5 mol) and potassium carbonate (34.55 g, 0.25 mol) were put in a reaction vessel, purged with nitrogen and refluxed for 48 hours. The generated solid was filtered, and the solvent was removed using an evaporator. Unreacted 2,4-pentanedione was then removed under reduced pressure using a diaphragm. Then, vacuum distillation was then used to obtain 3-n-butyl-2,4-pentanedione (43.25 g, yield 55%).

1. custompurged with nitrogen
2. temperaturerefluxed for 48 hours
3. filtrationThe generated solid was filtered
4. customthe solvent was removed
5. customan evaporator
6. customwas then removed under reduced pressure
7. distillationThen, vacuum distillation