反应详情

To a solution of isonicotinaldehyde (0.811 mL, 8.61 mmol) in DCM (30 mL) was added ethyl (triphenylphosphoranylidene)acetate (3.00 g, 8.61 mmol) in DCM (5 mL) dropwise. The reaction mixture was allowed to stir at rt for 5 h and then concentrated. The residue was purified by column chromatography to give ethyl (2E)-3-pyridin-4-ylacrylate (1.47 g, 96%). LCMS: (FA) ES+ 178.3.

1. concentrationconcentrated
2. customThe residue was purified by column chromatography