Hydrochloric Acid → {2-[(cyclobutylamino)carbonyl]-7,8-dihydro-1,6-naphthyridin-6(5H)-yl}acetic acid hydrochloride

HRID 1713132Notes

Reaction equation

HRID 1713132 reaction equation
[CH:1]1([NH:5][C:6]([C:8]2[CH:17]=[CH:16][C:15]3[CH2:14][N:13]([CH2:18][C:19]([O:21]C(C)(C)C)=[O:20])[CH2:12][CH2:11][C:10]=3[N:9]=2)=[O:7])[CH2:4][CH2:3][CH2:2]1.[ClH:26]>O1CCOCC1>[ClH:26].[CH:1]1([NH:5][C:6]([C:8]2[CH:17]=[CH:16][C:15]3[CH2:14][N:13]([CH2:18][C:19]([OH:21])=[O:20])[CH2:12][CH2:11][C:10]=3[N:9]=2)=[O:7])[CH2:2][CH2:3][CH2:4]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59463645HCID 59463645, compound

Product 1

HCID 66877729{2-[(cyclobutylamino)carbonyl]-7,8-dihydro-1,6-naphthyridin-6(5H)-yl}acetic acid hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

The oil obtained from step 2 is dissolved in dioxane (5 mL). 4 N HCl in dioxane (5 ml, 20 mmol) is added. The mixture is stirred at rt overnight. The solvent is removed and the residue is washed with ether to give the title compound as a white solid. MS (M+1): 290.1.

Workup

  1. customThe solvent is removed
  2. washthe residue is washed with ether

Sources & evidence

ORD record
ord-0e513dc03aeb4f0eaee41fd6d4289dc1
Source dataset
uspto-grants-2010_09
Patent number
US07795262B2

Reaction notes

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