ethyl pyrido[3,4-b]pyrazine-6(5H)-carboxylate → ethyl 7,8-dihydropyrido[3,4-b]pyrazine-6(5H)-carboxylate

HRID 1713139Notes

Reaction equation

HRID 1713139 reaction equation
[N:1]1[CH:6]=[CH:5][N:4]=[C:3]2[CH2:7][N:8]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH:9]=[CH:10][C:2]=12>CCOC(C)=O.[Pd]>[N:1]1[CH:6]=[CH:5][N:4]=[C:3]2[CH2:7][N:8]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH2:9][CH2:10][C:2]=12

Participants

4

Reactant 1

HCID 57420579ethyl pyrido[3,4-b]pyrazine-6(5H)-carboxylate

Product 1

HCID 57420580ethyl 7,8-dihydropyrido[3,4-b]pyrazine-6(5H)-carboxylate

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of ethyl pyrido[3,4-b]pyrazine-6(5H)-carboxylate (149 mg, 0.726 mmol) in EtOAc (25 mL) is added 10% Pd/C (100 mg). The mixture is hydrogenated at 30 psi. overnight. The mixture is filtered through Celite and the solvent removed under vacuum to yield the title compound. MS (+VE) m/z 208.16 (M++1).

Workup

  1. customovernight
  2. filtrationThe mixture is filtered through Celite
  3. customthe solvent removed under vacuum

Sources & evidence

ORD record
ord-10fcb71509cb4251818601b38389e3ee
Source dataset
uspto-grants-2010_09
Patent number
US07795262B2

Reaction notes

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