反应详情

To a solution of tert-butyl N-(3′-hydroxybiphenyl-4-ylmethyl)carbamate (0.300 g) in N,N-dimethylformamide (2.5 mL) was added potassium carbonate (0.194 g). Then 1-bromopropane (0.119 mL) was added, and the resulting mixture was stirred at room temperature for 9.5 hours. Potassium carbonate (0.180 g) and 1-bromopropane (0.110 mL) were added, and stirring was continued at room temperature for additional 14 hours. The reaction mixture was partitioned between diethyl ether (30 mL) and water (10 mL). The organic layer was washed successively with water (10 mL×2) and brine (10 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the title compound (0.333 g).

1. stirringstirring
2. waitwas continued at room temperature for additional 14 hours
3. customThe reaction mixture was partitioned between diethyl ether (30 mL) and water (10 mL)
4. washThe organic layer was washed successively with water (10 mL×2) and brine (10 mL)
5. dry with materialdried over anhydrous sodium sulfate
6. concentrationconcentrated under reduced pressure