反应详情

To an ice-cold solution of tert-butyl N-(3′-benzyloxy-biphenyl-4-ylmethyl)carbamate (0.500 g) in dichloromethane (2.6 mL) was added trifluoroacetic acid (0.976 mL), and the resulting mixture was stirred under ice-cooling for 1 hour. Saturated aqueous sodium hydrogen carbonate (15 mL) was added dropwise and the whole was extracted with dichloromethane (30 mL). The organic layer was washed with saturated aqueous sodium hydrogen carbonate/brine (1/1, 10 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the title compound (0.367 g).

1. temperaturecooling for 1 hour
2. extractionthe whole was extracted with dichloromethane (30 mL)
3. washThe organic layer was washed with saturated aqueous sodium hydrogen carbonate/brine (1/1, 10 mL)
4. dry with materialdried over anhydrous sodium sulfate
5. concentrationconcentrated under reduced pressure