反应详情

To a solution of pentanediol (1 mmol) in THF (5 ml) was added a catalytic amount of dimethyltin dichloride (0.01 mmol), solid K2CO3 (2.0 mmol) and benzoyl chloride (1.2 mmol), at room temperature. After stirring the mixture at room temperature until the diol disappeared (checked by TLC), the mixture was poured onto water and the organic portion was extracted with DCM. After evaporation of the solvent, a residue was obtained and purified by flash chromatography using a mixture of DCM/MeOH as eluent.

1. customat room temperature
2. additionthe mixture was poured onto water
3. extractionthe organic portion was extracted with DCM
4. customAfter evaporation of the solvent
5. customa residue was obtained
6. custompurified by flash chromatography
7. additiona mixture of DCM/MeOH as eluent