Hydrochloric Acid → HCID 59464293, compound

HRID 1713880Notes

Reaction equation

HRID 1713880 reaction equation
Cl.[N:2]1([C:8]2[N:13]=[CH:12][C:11]([NH:14][C:15]([C:17]3[O:21][C:20]([NH:22][C:23]4[CH:24]=[C:25]([CH:33]=[CH:34][CH:35]=4)[C:26]([O:28]C(C)(C)C)=[O:27])=[N:19][N:18]=3)=[O:16])=[CH:10][CH:9]=2)[CH2:7][CH2:6][O:5][CH2:4][CH2:3]1>O1CCOCC1>[N:2]1([C:8]2[N:13]=[CH:12][C:11]([NH:14][C:15]([C:17]3[O:21][C:20]([NH:22][C:23]4[CH:24]=[C:25]([CH:33]=[CH:34][CH:35]=4)[C:26]([OH:28])=[O:27])=[N:19][N:18]=3)=[O:16])=[CH:10][CH:9]=2)[CH2:7][CH2:6][O:5][CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59464085HCID 59464085, compound

Product 1

HCID 59464293HCID 59464293, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

4M HCl in 1,4-dioxane (70 mL) was added to tert-butyl 3-[(5-{[(6-morpholin-4-ylpyridin-3-yl)amino]carbonyl}-1,3,4-oxadiazol-2-yl)amino]benzoate (3.22 g, 6.90 mmol) and the suspension stirred for 18 hours. All volatiles were removed in vacuo and the residue triturated with Et2O (20 mL), the solid filtered, washed with Et2O (2×10 mL), hexane (2×10 mL) to give the title compound (2.80 g, 99%) as a cream powder; MS m/e (MH)+ 411

Workup

  1. customAll volatiles were removed in vacuo
  2. customthe residue triturated with Et2O (20 mL)
  3. filtrationthe solid filtered
  4. washwashed with Et2O (2×10 mL), hexane (2×10 mL)

Sources & evidence

ORD record
ord-678c891878184d76aeab19d89e286565
Source dataset
uspto-grants-2010_09
Patent number
US07795283B2

Reaction notes

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