Trifluoroacetic acid → HCID 68510603, compound

HRID 1714062Notes

Reaction equation

C([O:5][C:6](=[O:37])[CH2:7][N:8]1[CH2:15][C:14]2[CH:16]=[CH:17][CH:18]=[CH:19][C:13]=2[C:12]2=[C:20]([CH:31]3[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]3)[C:21]3[CH:22]=[CH:23][C:24]([C:27]([O:29][CH3:30])=[O:28])=[CH:25][C:26]=3[N:11]2[CH2:10][CH2:9]1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl.O>[CH:31]1([C:20]2[C:21]3[CH:22]=[CH:23][C:24]([C:27]([O:29][CH3:30])=[O:28])=[CH:25][C:26]=3[N:11]3[CH2:10][CH2:9][N:8]([CH2:7][C:6]([OH:37])=[O:5])[CH2:15][C:14]4[CH:16]=[CH:17][CH:18]=[CH:19][C:13]=4[C:12]=23)[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]1

Participants

Conditions

Temperature: 45 °C

Procedure

To a solution of methyl 6-(2-tert-butoxy-2-oxoethyl)-14-cyclohexyl-5,6,7,8-tetrahydroindolo[2,1-a][2,5]benzodiazocine-11-carboxylate in a 1:1 mixture DCM/H2O (0.05 M) was added a large excess (>100 eq) of TFA and the solution heated for 4 h at 45° C. The volatiles were then removed in vacuo and the crude product was used in the next step without further purification; MS (ES+) m/z 447 (M+H)+.

Workup

customThe volatiles were then removed in vacuo
customthe crude product was used in the next step without further purification

Sources & evidence

ORD record: ord-29176b7405734bfcbeac5a61fd76e712
Source dataset: uspto-grants-2010_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07795247B2

Reaction notes

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