HCID 16117409, compound → HCID 16117410, compound

HRID 1714133Notes

Reaction equation

HRID 1714133 reaction equation
C([N:8]1[CH2:20][C@H:19]2[C@H:11]([C:12](=[O:29])[C:13]3[C:18]2=[CH:17][C:16]([C:21]2[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][C:22]=2[Cl:28])=[CH:15][CH:14]=3)[CH2:10][CH2:9]1)C1C=CC=CC=1>CO.[OH-].[OH-].[Pd+2]>[Cl:28][C:22]1[CH:23]=[C:24]([Cl:27])[CH:25]=[CH:26][C:21]=1[C:16]1[CH:17]=[C:18]2[C:13](=[CH:14][CH:15]=1)[C:12](=[O:29])[C@H:11]1[C@@H:19]2[CH2:20][NH:8][CH2:9][CH2:10]1

Participants

4

Reactant 1

HCID 16117409HCID 16117409, compound

Product 1

HCID 16117410HCID 16117410, compound

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 887MethanolSolvent

Conditions

Temperature
20 °C

Procedure

To a solution of cis-3-benzyl-6-(2,4-dichloro-phenyl)-1,2,3,4,4a,9a-hexahydro-3-aza-fluoren-9-one (132 mg, 0.31 mmol) in MeOH (4.0 mL) was added Pd(OH)2 (26 mg, 20 wt %). The reaction mixture was stirred at 20° C. for 15 h under H2 atmosphere, filtered through celite and concentrated in vacuo to give the crude title compound.

Workup

  1. filtrationfiltered through celite and
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-95046f51d75a47c3afd9c27ad8218887
Source dataset
uspto-grants-2010_09
Patent number
US07795436B2

Reaction notes

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