HCID 16117541, compound → HCID 16117542, compound

HRID 1714138Notes

Reaction equation

HRID 1714138 reaction equation
C([N:8]1[CH2:20][C@H:19]2[C@H:11]([C:12](=[O:29])[C:13]3[C:18]2=[CH:17][CH:16]=[CH:15][C:14]=3[C:21]2[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][C:22]=2[Cl:28])[CH2:10][CH2:9]1)C1C=CC=CC=1>CO.[OH-].[OH-].[Pd+2]>[Cl:28][C:22]1[CH:23]=[C:24]([Cl:27])[CH:25]=[CH:26][C:21]=1[C:14]1[CH:15]=[CH:16][CH:17]=[C:18]2[C:13]=1[C:12](=[O:29])[C@H:11]1[C@@H:19]2[CH2:20][NH:8][CH2:9][CH2:10]1

Participants

4

Reactant 1

HCID 16117541HCID 16117541, compound

Product 1

HCID 16117542HCID 16117542, compound

Reagents, catalysts & solvents 2

HCID 9942167Palladium hydroxideCatalystHCID 887MethanolSolvent

Procedure

The title compound was prepared as a white solid (69 mg, 0.21) by following the procedure step A of example 4 from cis-3-benzyl-8-(2,4-dichloro-phenyl)-1,2,3,4,4a,9a-hexahydro-3-aza-fluoren-9-one (90 mg, 0.21 mmol) and Pd(OH)2 (18 mg, 20 wt %) in MeOH (3.0 mL): MS (ES) 332.1 (M+H).

Sources & evidence

ORD record
ord-f77422a6b0184566ba3ccb96c876d31f
Source dataset
uspto-grants-2010_09
Patent number
US07795436B2

Reaction notes

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