Trifluoroacetic acid → HCID 16117544, compound

HRID 1714139Notes

Reaction equation

HRID 1714139 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:10]=[CH:11][CH:12]=[C:13]2[C:21]=1[C:20](=O)[C@H:19]1[C@@H:14]2[CH2:15][NH:16][CH2:17][CH2:18]1.[SiH](CC)(CC)CC.FC(F)(F)C(O)=O>>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:10]=[CH:11][CH:12]=[C:13]2[C:21]=1[CH2:20][C@H:19]1[C@@H:14]2[CH2:15][NH:16][CH2:17][CH2:18]1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 12052TriethylsilaneHCID 16117542HCID 16117542, compound

Product 1

HCID 16117544HCID 16117544, compound

Procedure

The title compound was prepared as a white solid (22 mg, 0.069) by following the procedures of example 5 from cis-8-(2,4-dichloro-phenyl)-1,2,3,4,4a,9a-hexahydro-3-aza-fluoren-9-one (51 mg, 0.15 mmol), Et3SiH (79 mg, 0.68 mmol) and trifluoroacetic acid (175 mg, 1.5 mmol): MS (ES) 318.1 (M+H).

Sources & evidence

ORD record
ord-02b6ad34b3974dc38eefda9d6a2f4edb
Source dataset
uspto-grants-2010_09
Patent number
US07795436B2

Reaction notes

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