Hydrochloric Acid → HCID 57819938, compound

HRID 1714174Notes

Reaction equation

HRID 1714174 reaction equation
C[O:2][C:3](=[O:37])/[CH:4]=[CH:5]/[C:6]1[CH:11]=[CH:10][C:9]([CH:12]([N:26]([CH:35]=[O:36])[CH2:27][CH2:28][N:29]2[CH2:34][CH2:33][O:32][CH2:31][CH2:30]2)[C:13](=[O:25])[NH:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=2)=[CH:8][CH:7]=1.[OH-].[Na+].Cl>C1COCC1>[CH:35]([N:26]([CH:12]([C:13](=[O:25])[NH:14][C:15]1[CH:16]=[CH:17][C:18]([C:21]([F:23])([F:24])[F:22])=[CH:19][CH:20]=1)[C:9]1[CH:10]=[CH:11][C:6](/[CH:5]=[CH:4]/[C:3]([OH:37])=[O:2])=[CH:7][CH:8]=1)[CH2:27][CH2:28][N:29]1[CH2:34][CH2:33][O:32][CH2:31][CH2:30]1)=[O:36]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 57819985HCID 57819985, compound

Product 1

HCID 57819938HCID 57819938, compoundYield 41.1%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of (E)-3-{4-[[formyl-(2-morpholin-4-yl-ethyl)-amino]-(4-trifluoromethyl-phenylcarbamoyl)-methyl]-phenyl}-acrylic acid methyl ester (540 mg, 1.04 mmol) in THF (10 mL) was added aqueous 2M NaOH (3 ml) dropwise at 0 degrees Celcius, then this was stirred at room temperature overnight. The reaction was neutralized with dilute HCl solution, and the resulting precipitate filtered, and dried to obtain the desired product (216 mg, 41%). MS: calc'd 506 (MH+) exp 506 (MH+).

Workup

  1. filtrationthe resulting precipitate filtered
  2. customdried

Sources & evidence

ORD record
ord-eefa9f16e1c94218b78486bc63a31e29
Source dataset
uspto-grants-2010_09
Patent number
US07795315B2

Reaction notes

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