Acetyl chloride → HCID 178474971, compound

HRID 1714396Notes

Reaction equation

HRID 1714396 reaction equation
[NH2:1][C@H:2]1[CH2:7][CH2:6][C@H:5]([CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][CH:13]([O:16][C:17]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][C:18]=3[C:19]#[N:20])[CH2:12][CH2:11]2)[CH2:4][CH2:3]1.F[C:27](F)(F)[C:28](O)=[O:29].C(Cl)(=O)C>>[C:19]([C:18]1[CH:21]=[C:22]([F:25])[CH:23]=[CH:24][C:17]=1[O:16][CH:13]1[CH2:12][CH2:11][N:10]([CH2:9][CH2:8][C@H:5]2[CH2:6][CH2:7][C@H:2]([NH:1][C:28](=[O:29])[CH3:27])[CH2:3][CH2:4]2)[CH2:15][CH2:14]1)#[N:20]

Participants

4

Reactant 3

HCID 6367Acetyl chlorideHCID 6422Trifluoroacetic acidHCID 178510120HCID 178510120, compound

Product 1

HCID 178474971HCID 178474971, compound

Procedure

According to the synthesis of N-Trans(4-{2-[4-(4-Fluoro-phenoxy)-piperidin-1-yl]-ethyl}-cyclohexyl)-acetamide (example 8), the title compound was prepared from Trans 2-{1-[2-(4-Amino-cyclohexyl)-ethyl]-piperidin-4-yloxy}-5-fluoro-benzonitrile; trifluoroacetic acid salt and acetylchloride MS (m/e): 381.3 (M+H+).

Sources & evidence

ORD record
ord-14c4b195538e4d65aa477032a8243491
Source dataset
uspto-grants-2010_09
Patent number
US07795437B2

Reaction notes

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