Cyclobutanecarboxylic acid → HCID 178523670, compound

HRID 1714397Notes

Reaction equation

HRID 1714397 reaction equation
[Cl:1][C:2]1[CH:23]=[C:22]([F:24])[CH:21]=[C:20]([Cl:25])[C:3]=1[O:4][CH:5]1[CH2:10][CH2:9][N:8]([CH2:11][CH2:12][C@H:13]2[CH2:18][CH2:17][C@H:16]([NH2:19])[CH2:15][CH2:14]2)[CH2:7][CH2:6]1.[CH:26]1([C:30](O)=[O:31])[CH2:29][CH2:28][CH2:27]1>>[Cl:1][C:2]1[CH:23]=[C:22]([F:24])[CH:21]=[C:20]([Cl:25])[C:3]=1[O:4][CH:5]1[CH2:10][CH2:9][N:8]([CH2:11][CH2:12][C@H:13]2[CH2:14][CH2:15][C@H:16]([NH:19][C:30]([CH:26]3[CH2:29][CH2:28][CH2:27]3)=[O:31])[CH2:17][CH2:18]2)[CH2:7][CH2:6]1

Participants

3

Reactant 2

HCID 19494Cyclobutanecarboxylic acidHCID 178511520HCID 178511520, compound

Product 1

HCID 178523670HCID 178523670, compound

Procedure

According to the synthesis of example 1 the title compound was prepared from Trans(4-{2-[4-(2,6-dichloro-4-fluoro-phenoxy)-piperidin-1-yl]-ethyl}-cyclohexyl)-amine and cyclobutanecarboxylic acid. Preparative HPLC on reversed phase eluting with acetonitrile/water yielded the title compound. MS (m/e): 471.0 (M+H+).

Workup

  1. washPreparative HPLC on reversed phase eluting with acetonitrile/water

Sources & evidence

ORD record
ord-d371a5b5f7364227bfd418b2f548320c
Source dataset
uspto-grants-2010_09
Patent number
US07795437B2

Reaction notes

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