反应详情

温度

140 °C

In 100 ml of ethylene glycol 8.6 g of anhydrous piperazine was dissolved, and to which 7-chlorofuro[2,3-c]pyridine was added, followed by an overnight's stirring at 140° C. After cooling, saturated aqueous sodium hydrogencarbonate solution was added to the solution, which was then extracted with chloroform. The organic layer was dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. The residue was purified on silica gel column chromatography to provide 1.52 g (75%) of 7-piperazin-1-ylfuro[2,3-c]pyridine.

1. temperatureAfter cooling
2. extractionwas then extracted with chloroform
3. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
4. distillationthe solvent was distilled off under reduced pressure
5. customThe residue was purified on silica gel column chromatography