Triethylamine → HCID 57647127, compound

HRID 1714876Notes

Reaction equation

Cl[C:2]1[N:7]=[N:6][C:5]([C:8]([NH:10][CH2:11][CH2:12][CH:13]([CH3:15])[CH3:14])=[O:9])=[CH:4][CH:3]=1.[C:16]1([CH2:22][CH2:23][CH:24]2[CH2:28][CH2:27][NH:26][CH2:25]2)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.CCN(CC)CC>CN1CCCC1=O>[CH3:14][CH:13]([CH3:15])[CH2:12][CH2:11][NH:10][C:8]([C:5]1[N:6]=[N:7][C:2]([N:26]2[CH2:27][CH2:28][CH:24]([CH2:23][CH2:22][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH2:25]2)=[CH:3][CH:4]=1)=[O:9]

Participants

Conditions

Temperature: 120 °C

Procedure

To a solution of 6-chloro-N-(3-methylbutyl)pyridazine-3-carboxamide (20 mg, 0.088 mmol) and 3-(2-phenylethyl)pyrrolidine (23 mg, 0.13 mmol) in 1-methyl-2-pyrrolidinone (1 mL) was added Et3N (25 μL, 0.18 mmol) at room temperature. The mixture was stirred at 120° C. overnight. The reaction was then concentrated and the residue purified using a semi-prep HPLC/MS to give the title compound. MS (+ESI) m/z 367 (MH+).

Workup

concentrationThe reaction was then concentrated
customthe residue purified

Sources & evidence

ORD record: ord-929c269cdb1e46239f4c70ee395e876f
Source dataset: uspto-grants-2010_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07799787B2

Reaction notes

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