HCID 57647141, compound → HCID 68508869, compound

HRID 1714885Notes

Reaction equation

HRID 1714885 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([N:10]2[CH2:15][CH2:14][CH:13]([O:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[C:23]([F:26])([F:25])[F:24])[CH2:12][CH2:11]2)=[N:8][CH:9]=1)([O-])=O>CCOC(C)=O.[Pd]>[F:26][C:23]([F:24])([F:25])[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=1[O:16][CH:13]1[CH2:12][CH2:11][N:10]([C:7]2[N:8]=[CH:9][C:4]([NH2:1])=[CH:5][CH:6]=2)[CH2:15][CH2:14]1

Participants

4

Reactant 1

HCID 57647141HCID 57647141, compound

Product 1

HCID 68508869HCID 68508869, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

A mixture of 5-nitro-2-{4-[2-(trifluoromethyl)phenoxy]piperidin-1-yl}pyridine (1.6 g, 4.4 mmol) and 10% Pd/C (300 mg) in EtOAc (100 mL) was hydrogenated at 50 psi overnight. The catalyst was filtered off through celite. The filtrate was removed in vacuo to give the title compound as a light brown gum.

Workup

  1. customwas hydrogenated at 50 psi overnight
  2. filtrationThe catalyst was filtered off through celite
  3. customThe filtrate was removed in vacuo

Sources & evidence

ORD record
ord-9cd6f92483534096959bdf2675483c9c
Source dataset
uspto-grants-2010_09
Patent number
US07799787B2

Reaction notes

Loading…