Dimethylformamide dimethyl acetal → HCID 59028789, compound

HRID 1715061Notes

Reaction equation

HRID 1715061 reaction equation
[C:1]1([S:7]([C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[C:16]([CH2:20][NH2:21])=[CH:15][CH:14]=[CH:13]3)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CO[CH:24](OC)[N:25]([CH3:27])[CH3:26]>>[C:1]1([S:7]([C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[C:16]([CH2:20][N:21]=[CH:24][N:25]([CH3:27])[CH3:26])=[CH:15][CH:14]=[CH:13]3)(=[O:9])=[O:8])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

3

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 59028770C-(6-Benzenesulfonyl-naphthalen-1-yl)-methylamine

Product 1

HCID 59028789HCID 59028789, compound

Conditions

Temperature
95 °C

Procedure

C-(6-Benzenesulfonyl-naphthalen-1-yl)-methylamine is added to dimethylformamide dimethyl acetal, and the reaction mixture is heated to 95° C. The reaction mixture is cooled and quenched by addition of water, and the resulting aqueous mixture is extracted with EtOAc. The organic layer is washed with water, brine, dried (MgSO4), and evaporated under reduced pressure to give N′-(6-Benzenesulfonyl-naphthalen-1-ylmethyl)-N,N-dimethyl-formamidine.

Workup

  1. temperatureThe reaction mixture is cooled
  2. customquenched by addition of water
  3. extractionthe resulting aqueous mixture is extracted with EtOAc
  4. washThe organic layer is washed with water, brine
  5. dry with materialdried (MgSO4)
  6. customevaporated under reduced pressure

Sources & evidence

ORD record
ord-e92dc842c2c04a3993c40d553d1e33a1
Source dataset
uspto-grants-2010_09
Patent number
US07799797B2

Reaction notes

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