Methylamine → HCID 59028782, compound

HRID 1715066Notes

Reaction equation

HRID 1715066 reaction equation
C([O:3][C:4](=O)[CH2:5][NH:6][CH2:7][C:8]1[C:17]2[C:12](=[CH:13][C:14]([S:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)(=[O:20])=[O:19])=[CH:15][CH:16]=2)[CH:11]=[CH:10][CH:9]=1)C.[CH3:28][NH2:29]>CO>[C:21]1([S:18]([C:14]2[CH:13]=[C:12]3[C:17](=[CH:16][CH:15]=2)[C:8]([CH2:7][NH:6][CH2:5][C:4]([NH:29][CH3:28])=[O:3])=[CH:9][CH:10]=[CH:11]3)(=[O:20])=[O:19])[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 59028781HCID 59028781, compound

Product 1

HCID 59028782HCID 59028782, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

[(6-Benzenesulfonyl-naphthalen-1-ylmethyl)-amino]-acetic acid ethyl ester is added to methylamine in methanol, and the solution is stirred at room temperature, then concentrated under reduced pressure. The oil is dissolved in ethanol and 1N HCl in diethyl ether is added to precipitate 2-[(6-benzenesulfonyl-naphthalen-1-ylmethyl)-amino]-N-methyl-acetamide as a hydrochloride salt.

Workup

  1. concentrationconcentrated under reduced pressure
  2. dissolutionThe oil is dissolved in ethanol
  3. addition1N HCl in diethyl ether is added
  4. customto precipitate 2-[(6-benzenesulfonyl-naphthalen-1-ylmethyl)-amino]-N-methyl-acetamide as a hydrochloride salt

Sources & evidence

ORD record
ord-734053a8563941c48289a84ce57d8544
Source dataset
uspto-grants-2010_09
Patent number
US07799797B2

Reaction notes

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