Hydrochloric Acid → HCID 68509200, compound

HRID 1715126Notes

Reaction equation

HRID 1715126 reaction equation
C([N:4]1[CH2:9][CH2:8][CH:7]([N:10]2[C:18]3[CH:17]=[CH:16][NH:15][C:14](=[O:19])[C:13]=3[N:12]=[CH:11]2)[CH2:6][CH2:5]1)(=O)C.[ClH:20]>C(O)C>[ClH:20].[ClH:20].[NH:4]1[CH2:5][CH2:6][CH:7]([N:10]2[C:18]3[CH:17]=[CH:16][NH:15][C:14](=[O:19])[C:13]=3[N:12]=[CH:11]2)[CH2:8][CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59465531HCID 59465531, compound

Product 1

HCID 68509200HCID 68509200, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 1-(1-acetyl-piperidin-4-yl)-1,5-dihydro-imidazo[4,5-c]pyridin-4-one (6.00 g, 23.05 mmol) in ethanol (48 mL) was added conc. HCl (24 mL) and the reaction mixture heated to reflux for 16 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ISP): 219.2 [M+H]+.

Workup

  1. temperaturethe reaction mixture heated
  2. temperatureto reflux for 16 h
  3. customThe solvent was removed under reduced pressure
  4. customthe crude product used in the consecutive step without further purification

Sources & evidence

ORD record
ord-ce132395f3e9492aaeb4e79b3a814736
Source dataset
uspto-grants-2010_09
Patent number
US07799806B2

Reaction notes

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