Cesium carbonate → 2-([6-(Methylsulfonyl)pyridin-3-yl]oxy)-5-nitrobenzaldehyde

HRID 1715310Notes

Reaction equation

HRID 1715310 reaction equation
C(=O)([O-])[O-].[Cs+].[Cs+].CN1CCCC1=O.Cl[C:15]1[CH:22]=[CH:21][C:20]([N+:23]([O-:25])=[O:24])=[CH:19][C:16]=1[CH:17]=[O:18].[CH3:26][S:27]([C:30]1[N:35]=[CH:34][C:33]([OH:36])=[CH:32][CH:31]=1)(=[O:29])=[O:28]>O>[CH3:26][S:27]([C:30]1[N:35]=[CH:34][C:33]([O:36][C:15]2[CH:22]=[CH:21][C:20]([N+:23]([O-:25])=[O:24])=[CH:19][C:16]=2[CH:17]=[O:18])=[CH:32][CH:31]=1)(=[O:29])=[O:28]

Participants

6

Reactant 4

HCID 10796Cesium carbonateHCID 13387N-methyl-2-pyrrolidoneHCID 729332-Chloro-5-nitrobenzaldehydeHCID 231451966-(Methylsulfonyl)pyridin-3-ol

Product 1

HCID 866301162-([6-(Methylsulfonyl)pyridin-3-yl]oxy)-5-nitrobenzaldehyde

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Cesium carbonate (10 g) was added to an N-methylpyrrolidinone (70 ml) solution of 2-chloro-5-nitrobenzaldehyde (5.0 g) and 6-(methylsulfonyl)-3-pyridinol (5 g) obtained in Reference Example 2, and stirred at room temperature for 3 hours. Water was added, then the formed crystal was collected by filtration to obtain the entitled compound as a pale brown solid.

Workup

  1. customobtained in Reference Example 2
  2. filtrationthe formed crystal was collected by filtration

Sources & evidence

ORD record
ord-a5d02a002bdb411eb8d2fa507a969e05
Source dataset
uspto-grants-2010_09
Patent number
US07799820B2

Reaction notes

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