Hydrochloric Acid → HCID 12001701, compound

HRID 1715452Notes

Reaction equation

C(OC([N:8]1[CH2:13][CH2:12][C@H:11]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH2:21][CH2:22][O:23][C:24]3[C:29]([Cl:30])=[CH:28][C:27]([CH3:31])=[CH:26][C:25]=3[Cl:32])=[CH:16][CH:15]=2)[C@@H:10]([C:33](=[O:47])[N:34]([CH:44]2[CH2:46][CH2:45]2)[CH2:35][C:36]2[CH:41]=[CH:40][CH:39]=[C:38]([CH3:42])[C:37]=2[CH3:43])[CH2:9]1)=O)(C)(C)C.Cl>C(Cl)Cl.O1CCOCC1>[CH:44]1([N:34]([CH2:35][C:36]2[CH:41]=[CH:40][CH:39]=[C:38]([CH3:42])[C:37]=2[CH3:43])[C:33]([C@@H:10]2[C@@H:11]([C:14]3[CH:15]=[CH:16][C:17]([O:20][CH2:21][CH2:22][O:23][C:24]4[C:29]([Cl:30])=[CH:28][C:27]([CH3:31])=[CH:26][C:25]=4[Cl:32])=[CH:18][CH:19]=3)[CH2:12][CH2:13][NH:8][CH2:9]2)=[O:47])[CH2:45][CH2:46]1

Participants

Conditions

Temperature: 0 °C

Procedure

Compound D3 (0.068 g, 0.10 mmol) was dissolved in CH2Cl2 (1 mL) and the sol. was cooled to 0° C. 4M HCl in dioxane (1 mL) was added and the reaction mixture was stirred for 1 h at rt. The solvents were evaporated under reduced pressure. Purification of the residue by HPLC yielded the title compound (37 mg, 63%). LC-MS: tR=0.95 min, ES+=581.44.

Workup

customThe solvents were evaporated under reduced pressure
customPurification of the residue by HPLC

Sources & evidence

ORD record: ord-784237a0ca7a45d49c11c51076692239
Source dataset: uspto-grants-2010_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07799805B2

Reaction notes

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