Hydrochloric Acid → HCID 178507456, compound

HRID 1715525Notes

Reaction equation

HRID 1715525 reaction equation
[OH:1][C:2]1[C:11]([OH:12])=[N:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][C:8]=2[N+:13]([O-])=O)[N:3]=1.C(=O)([O-])[O-].[K+].[K+].Cl>CO.O>[OH:1][C:2]1[C:11]([OH:12])=[N:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][C:8]=2[NH2:13])[N:3]=1

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 11430Potassium CarbonateHCID 178526554HCID 178526554, compound

Product 1

HCID 178507456HCID 178507456, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

2.00 g of 2,3-dihydroxy-5-nitroquinoxaline was dissolved in 100 g of a 1:1 methanol and dioxane solvent, after which the reaction system was well purged with argon, followed by further addition of 1.00 g of 5% Pd/C (hydrous). Thereafter, the system was purged with hydrogen, followed by reaction at room temperature for 20 hours. After completion of the reaction, the reaction product was dispersed in a solution of 6.00 g of potassium carbonate in 130 ml of water and then dissolved therein. 35% hydrochloric acid was gradually added to the solution obtained after filtration thereby obtaining a precipitate.

Workup

  1. customdioxane solvent, after which the reaction system was well purged with argon
  2. additionfollowed by further addition of 1.00 g of 5% Pd/C (hydrous)
  3. customThereafter, the system was purged with hydrogen
  4. customfollowed by reaction at room temperature for 20 hours
  5. customAfter completion of the reaction
  6. dissolutiondissolved
  7. customobtained
  8. filtrationafter filtration
  9. customthereby obtaining a precipitate

Sources & evidence

ORD record
ord-9e7b94316c47418cb5bc74f1abdea638
Source dataset
uspto-grants-2010_09
Patent number
US07799894B2

Reaction notes

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