HCID 86612732, compound → HCID 86612731, compound

HRID 1715543Notes

Reaction equation

HRID 1715543 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[C:23]3[C:18](=[CH:19][CH:20]=[CH:21][C:22]=3[NH2:24])[NH:17][C:16]3[C:15]4[CH:25]=[CH:26][CH:27]=[CH:28][C:14]=4[C:13]4[CH:29]=[CH:30][CH:31]=[CH:32][C:12]=4[C:11]2=3)=[CH:6][CH:5]=1)([O-])=O>O1CCCC1>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[C:23]3[C:18](=[CH:19][CH:20]=[CH:21][C:22]=3[NH2:24])[NH:17][C:16]3[C:15]4[CH:25]=[CH:26][CH:27]=[CH:28][C:14]=4[C:13]4[CH:29]=[CH:30][CH:31]=[CH:32][C:12]=4[C:11]2=3)=[CH:6][CH:5]=1

Participants

3

Reactant 1

HCID 86612732HCID 86612732, compound

Product 1

HCID 86612731HCID 86612731, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

4.5 g (10.8 mmol) of N-4-nitrophenyl-10-aminodibenzo(A,C)phenazine was dissolved in 200 ml of tetrahydrofuran, and the reaction container was purged with nitrogen. Thereafter, 4.6 g of 5% Pd/C (hydrous) was added, followed by sufficient purging with nitrogen again. This system was purged with hydrogen, followed by reaction at room temperature for 10 hours. After completion of the reaction, the system was filtered, and the resulting filtration residue was further washed with tetrahydrofuran and purified with a column to obtain the intended product.

Workup

  1. customthe reaction container was purged with nitrogen
  2. additionThereafter, 4.6 g of 5% Pd/C (hydrous) was added
  3. customby sufficient purging with nitrogen again
  4. customThis system was purged with hydrogen
  5. customfollowed by reaction at room temperature for 10 hours
  6. customAfter completion of the reaction
  7. filtrationthe system was filtered
  8. filtrationthe resulting filtration residue
  9. washwas further washed with tetrahydrofuran
  10. custompurified with a column
  11. customto obtain the intended product

Sources & evidence

ORD record
ord-0bcd68d5b684425c8a6a1c7d299be1cd
Source dataset
uspto-grants-2010_09
Patent number
US07799894B2

Reaction notes

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