反应详情

To a suspension of 7.79 g of methyl 2-aminohexanoate hydrochloride in 70 ml of dichloromethane were added 8.67 g of triethylamine (manufactured by WAKO PURE CHEMICAL INDUSTRIES LTD.), 7.74 g of anhydrous magnesium sulfate, and 4.55 g of benzaldehyde and the resultant was stirred overnight at room temperature. The reaction suspension was then filtered and the filtrate was concentrated. 280 ml of ether was added to the residue and the resultant suspension was filtered and the filtrate was concentrated. Again, 280 ml of ether was added to the residue and filtration and concentration were similarly repeated to obtain 10.0 g of the title compound.

1. filtrationThe reaction suspension was then filtered
2. concentrationthe filtrate was concentrated
3. addition280 ml of ether was added to the residue
4. filtrationthe resultant suspension was filtered
5. concentrationthe filtrate was concentrated
6. additionAgain, 280 ml of ether was added to the residue and filtration and concentration