Trifluoroacetic acid → HCID 19049649, compound

HRID 1716266Notes

Reaction equation

HRID 1716266 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][N:13]1[CH2:18][CH2:17][N:16]([CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][NH:24]C(OC(C)(C)C)=O)[CH2:15][CH2:14]1)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[NH2:24][CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][N:16]1[CH2:17][CH2:18][N:13]([CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][NH2:7])[CH2:14][CH2:15]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68676140HCID 68676140, compound

Product 1

HCID 19049649HCID 19049649, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of {5-[4-(5-tert-butoxycarbonylamino-pentyl)-piperazin-1-yl]-pentyl}-carbamic acid tert-butyl ester (329 mg, 0.72 mmol) in DCM (10 mL) is treated with trifluoracetic acid (1 mL). The reaction was left to stir at RT for 4 days and then the solvent is removed in vacuo. The material was used crude and conversion was assumed quantitative to produce 5-[4-(5-amino pentyl)-piperazin-1-yl]-pentylamine.

Workup

  1. waitThe reaction was left
  2. customthe solvent is removed in vacuo

Sources & evidence

ORD record
ord-a037e61418314fe8846f7437b46f431a
Source dataset
uspto-grants-2010_09
Patent number
US07803804B2

Reaction notes

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