HCID 59467988, compound → HCID 44455124, compound

HRID 1716304Notes

Reaction equation

HRID 1716304 reaction equation
C([O:8][N:9]1[CH2:14][CH2:13][CH2:12][C@@H:11]([NH:15][S:16]([C:19]2[CH:24]=[CH:23][C:22]([O:25][C:26]3[CH:31]=[CH:30][C:29]([Cl:32])=[CH:28][CH:27]=3)=[CH:21][CH:20]=2)(=[O:18])=[O:17])[C:10]1=[O:33])C1C=CC=CC=1>CS(O)(=O)=O>[Cl:32][C:29]1[CH:28]=[CH:27][C:26]([O:25][C:22]2[CH:21]=[CH:20][C:19]([S:16]([NH:15][C@@H:11]3[CH2:12][CH2:13][CH2:14][N:9]([OH:8])[C:10]3=[O:33])(=[O:17])=[O:18])=[CH:24][CH:23]=2)=[CH:31][CH:30]=1

Participants

3

Reactant 1

HCID 59467988HCID 59467988, compound

Product 1

HCID 44455124HCID 44455124, compound

Reagents, catalysts & solvents 1

HCID 6395Methanesulfonic AcidSolvent

Procedure

A solution of (R)—N-(1-benzyloxy-2-oxo-piperidin-3-yl)-4-(4-chloro-phenoxy)-benzenesulfonamide (0.1 g) in step A in MeSO3H (1.5 mL) was stirred at room temperature under N2 for 16 h. The reaction was quenched with ice-water and the precipitate was filtered. The white solid was washed with water, Et2O/hexanes (1:5) to give the titled compound. MS (EI) 397 (M+H)+.

Workup

  1. customThe reaction was quenched with ice-water
  2. filtrationthe precipitate was filtered
  3. washThe white solid was washed with water, Et2O/hexanes (1:5)

Sources & evidence

ORD record
ord-5330122b5176420d9d55ae84cef9a84c
Source dataset
uspto-grants-2010_09
Patent number
US07803793B2

Reaction notes

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