反应详情

To a solution of N-ethyl-3-hydroxy-4-nitrobenzamide (2.1 g) obtained in Example 74a) in acetone (100 ml) were added potassium carbonate (1.4 g) and bromoethane (0.75 ml), and the mixture was heated under reflux overnight. After cooling to room temperature, the solvent was evaporated under reduced pressure. Water and ethyl acetate were added to the residue, and the organic layer was fractionated. The organic layer was dried over sodium sulfate, and the solvent was evaporated under reduced pressure to give the title compound as a pale-brown solid (0.72 g, 30%).

1. temperaturethe mixture was heated
2. temperatureunder reflux overnight
3. customthe solvent was evaporated under reduced pressure
4. additionWater and ethyl acetate were added to the residue
5. dry with materialThe organic layer was dried over sodium sulfate
6. customthe solvent was evaporated under reduced pressure