反应详情

To a solution of N-ethyl-3-hydroxy-4-nitrobenzamide (2.10 g) obtained in Example 131a) in acetone (100 ml) were added ethyl bromide (0.75 ml) and potassium carbonate (1.38 g), and the reaction mixture was heated under reflux overnight. The reaction mixture was allowed to cool to room temperature and the solvent was evaporated under reduced pressure. Ethyl acetate and water were added to the residue. The organic layer was dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give the title compound as a pale-brown solid (0.72 g, 30%).

1. temperaturethe reaction mixture was heated
2. temperatureunder reflux overnight
3. customthe solvent was evaporated under reduced pressure
4. additionEthyl acetate and water were added to the residue
5. dry with materialThe organic layer was dried over anhydrous sodium sulfate
6. customthe solvent was evaporated under reduced pressure