HCID 68514103, compound → HCID 136104424, compound

HRID 1717375Notes

Reaction equation

HRID 1717375 reaction equation
[CH:1]1([NH:4][C:5]([C:7]2[N:8]=[N:9][N:10]([C:38]3[CH:43]=[CH:42][C:41]([C:44]([NH:46][CH2:47][CH3:48])=[O:45])=[CH:40][CH:39]=3)[C:11]=2/[CH:12]=[CH:13]/[C:14]2[CH:15]=[N:16][N:17](C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)[CH:18]=2)=[O:6])[CH2:3][CH2:2]1>FC(F)(F)C(O)=O>[CH:1]1([NH:4][C:5]([C:7]2[N:8]=[N:9][N:10]([C:38]3[CH:39]=[CH:40][C:41]([C:44]([NH:46][CH2:47][CH3:48])=[O:45])=[CH:42][CH:43]=3)[C:11]=2/[CH:12]=[CH:13]/[C:14]2[CH:15]=[N:16][NH:17][CH:18]=2)=[O:6])[CH2:2][CH2:3]1

Participants

3

Reactant 1

HCID 68514103HCID 68514103, compound

Product 1

HCID 136104424HCID 136104424, compoundYield 83.6%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

N-Cyclopropyl-1-{4-[(ethylamino)carbonyl]phenyl}-5-[(E)-2-(1-trityl-1H-pyrazol-4-yl)vinyl]-1H-1,2,3-triazole-4-carboxamide (910 mg) obtained in Example 325a) was dissolved in trifluoroacetic acid (5 ml), and the mixture was stirred at room temperature for 30 min. The reaction mixture was concentrated under reduced pressure, and the obtained residue was triturated with water to give the title compound as a white powder (470 mg).

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customthe obtained residue was triturated with water

Sources & evidence

ORD record
ord-cde7a0cbc2da4fcd985c23de0f782ba8
Source dataset
uspto-grants-2010_09
Patent number
US07803822B2

Reaction notes

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