反应详情

温度

60 °C

(4-[(Cyclopropylamino)carbonyl]-1-{4-[(ethylamino)carbonyl]phenyl}-1H-1,2,3-triazol-5-yl)propyl methanesulfonate (218 mg, 0.5 mmol) obtained in Example 1201a) and 60% sodium hydride (24 mg, 0.6 mmol, 1.2 eq.) were dissolved in DMF (5 ml) and the mixture was stirred at 60° C. for 3 hr. The reaction mixture was diluted with water (10 ml), and the precipitate was collected by filtration, washed with water and dried to give the title compound as a white powder (85 mg, 50.1%).

1. filtrationthe precipitate was collected by filtration
2. washwashed with water
3. customdried