Hydrochloric Acid → HCID 13454590, compound

HRID 1719124Notes

Reaction equation

HRID 1719124 reaction equation
[CH2:1]([O:3][C:4]([CH2:6][NH:7][CH:8]1[C:14](=[O:15])[N:13](OC(C)(C)C)[C:12]2[CH:21]=[CH:22][CH:23]=[CH:24][C:11]=2[S:10][CH2:9]1)=[O:5])[CH3:2].[ClH:25]>O1CCOCC1>[ClH:25].[C:4]([CH2:6][N:13]1[C:12]2[CH:21]=[CH:22][CH:23]=[CH:24][C:11]=2[S:10][CH2:9][CH:8]([NH:7][CH2:6][C:4]([O:3][CH2:1][CH3:2])=[O:5])[C:14]1=[O:15])([OH:5])=[O:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 20267550HCID 20267550, compound

Product 1

HCID 13454590HCID 13454590, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

1.25 g of the 3-ethoxycarbonylmethylamino- 5-t-butoxy-2,3-dihydro-1,5-benzothiazepin-4(5H)-one obtained in Example 14 was dissolved in 10 ml of a 6N solution of hydrogen chloride in dioxane and then reacted at room temperature for an hour. After this solution was concentrated under reduced pressure, ether was added thereto so as to cause crystallization. Thus, there was obtained 720 mg of the desired compound. When heated to determine its melting point, this compound decomposed at 248° C.

Workup

  1. customreacted at room temperature for an hour
  2. concentrationAfter this solution was concentrated under reduced pressure, ether
  3. additionwas added
  4. customcrystallization

Sources & evidence

ORD record
ord-d62508f8d31943e8809f7d5620095897
Source dataset
uspto-grants-1985_09
Patent number
US04539150

Reaction notes

Loading…