反应详情

5,6,7,8-tetrahydro-1-naphthol (5.9 g, 39mM) was added to a suspension of potassium carbonate (8.3 g, 60mM) in acetone (100 ml) and heated under reflux for 0.5 hour. Benzyl bromide (7.5 g, 43.8mM) was then added and the mixture was heated under reflux for a further 3 days with stirring. The resulting suspension was filtered and the filtrate was evaporated under reduced pressure to give an oil. This oil was dissolved in ether, washed with water, dried (sodium sulphate) and evaporated to giving an oil which was distilled under high vacuum to give the benzyl ether (3) (9.4 g, b.p. 170°-176° C. at 0.8 mm Hg).

1. temperatureheated
2. temperatureunder reflux for 0.5 hour
3. temperaturethe mixture was heated
4. temperatureunder reflux for a further 3 days
5. filtrationThe resulting suspension was filtered
6. customthe filtrate was evaporated under reduced pressure
7. customto give an oil
8. washwashed with water
9. dry with materialdried (sodium sulphate)
10. customevaporated
11. customto giving an oil which
12. distillationwas distilled under high vacuum