Hydrogen Peroxide → 2-Methyl-1lambda~4~,4-thiazinane-1,3-dione

HRID 1719203Notes

Reaction equation

HRID 1719203 reaction equation
[CH3:1][CH:2]1[S:7][CH2:6][CH2:5][NH:4][C:3]1=[O:8].[OH:9]O>C(O)=O.C(OC(=O)C)(=O)C>[CH3:1][CH:2]1[S:7](=[O:9])[CH2:6][CH2:5][NH:4][C:3]1=[O:8]

Participants

5

Reactant 2

HCID 784Hydrogen PeroxideHCID 955282-Methyl-thioMorpholin-3-one

Product 1

HCID 704993132-Methyl-1lambda~4~,4-thiazinane-1,3-dione

Reagents, catalysts & solvents 2

HCID 284Formic AcidSolventHCID 7918Acetic AnhydrideSolvent

Conditions

Temperature
0 °C

Procedure

To a solution of 9 g of 2-methyl-3-thiamorpholinone in a mixture of 50 cm3 of formic acid and 10 cm3 of acetic anhydride, cooled to 0° C., 7 cm3 of H2O2 at 110 vol. are slowly added. After an 18 hour reaction period, the solution is concentrated under reduced pressure. The resulting product is dissolved in chloroform and the chloroform solution is deposited on a silica gel column.

Workup

  1. customAfter an 18 hour reaction period
  2. concentrationthe solution is concentrated under reduced pressure
  3. dissolutionThe resulting product is dissolved in chloroform

Sources & evidence

ORD record
ord-9e1cfce60b6e4b108c1b6d2dfc7f2bf2
Source dataset
uspto-grants-1985_09
Patent number
US04539320

Reaction notes

Loading…