反应详情

A mixture of (6R,7R)-2,2-dimethyl-7-isocyano-1-aza-3-oxabicyclo[4.2.0]octan-8-one (150 mg), tributyltinhydride (0.263 ml), and azobisisobutyronitrile (14 mg) in benzene (4.5 ml) was refluxed for 15 minutes. The resulting solution was chromatographed on silica gel (4.5 g) eluting with a mixture of benzene and acetone (15:1-16:1) to give the crude product (140 mg) as an oil, which was purified by silica gel (5 g) chromatography (eluate: a mixture of methylene chloride and ethyl acetate 30:1-5:1) to give (6R)-2,2-dimethyl-1-aza-3-oxabicycle[4.2.0]-octan-8-one (98 mg) as an oil.

1. temperaturewas refluxed for 15 minutes
2. customThe resulting solution was chromatographed on silica gel (4.5 g)
3. washeluting with a mixture of benzene and acetone (15:1-16:1)
4. customto give the crude product (140 mg) as an oil, which
5. customwas purified by silica gel (5 g) chromatography (eluate
6. additiona mixture of methylene chloride and ethyl acetate 30:1-5:1)