反应详情

A mixture of 1.5180 g of 1,3-dihydroxynaphthalene and 1.70 g of anhydrous potassium carbonate in 10 ml of anhydrous acetone was stirred at room temperature for 1 hour. Methyl bromoacetate (0.91 ml) was added and stirring at room temperature was continued for 50 hours. The solvent was removed in vacuo and the residue was acidified and extracted with ethyl acetate. The dried (magnesium sulfate) extract was concentrated in vacuo and the product was purified by high pressure liquid chromatography using 20% ethyl acetate-toluene to give 0.419 g (19% yield) of [(4-hydroxy-2-naphthalenyl)oxy]acetic acid methyl ester as an oil.

1. stirringstirring at room temperature
2. waitwas continued for 50 hours
3. customThe solvent was removed in vacuo
4. extractionextracted with ethyl acetate
5. dry with materialThe dried (magnesium sulfate)
6. extractionextract
7. concentrationwas concentrated in vacuo
8. customthe product was purified by high pressure liquid chromatography